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Published on: 2010-02-19
Released on: 2002-12-05
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The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans. Molecular Motors in Neurons: Transport Mechanisms and ... The kinesin dynein and myosin superfamily molecular motors have fundamental roles in neuronal function plasticity morphogenesis and survival by transporting ... Minigene - Wikipedia A minigene is a minimal gene fragment that includes an exon and the control regions necessary for the gene to express itself in the same way as a wild type gene fragment. Protein Phosphorylation as a Key Mechanism of mTORC1/2 ... Figure 3. Nutrients regulation of mTORC signaling. mTORC1 could be activated by amino acids through few proposed molecular mechanisms. In the response to amino acid ... RNA splicing - Wikipedia Splicing pathways. Several methods of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for ... Molecular mechanisms of heavy metal hyperaccumulation and ... Introduction. Heavy metals are the main group of inorganic contaminants and a considerable large area of land is contaminated with them due to use of sludge or ... Regulation of cancer cell metabolism : Article : Nature ... The link between cancer and altered metabolism is not new as many observations made during the early period of cancer biology research identified metabolic changes ... TP53 tumor protein p53 [ (human)] - ncbi.nlm.nih.gov This gene encodes a tumor suppressor protein containing transcriptional activation DNA binding and oligomerization domains. The encoded protein responds to diverse ... Laboratory of Dynamic Cell Biology - Hatoh T. Maeda T. Takeuchi K. Ogikubo O. Uchiyama S. Otsuka T. Ohkubo I. and Ogita H. 2012 Domain 5 of high molecular weight kininogen inhibits ... Molecular mechanisms of epithelialmesenchymal transition ... Previous article. Nature Reviews Molecular Cell Biology Review Post-translational modifications of intermediate filament proteins: mechanisms and functions MYC v-myc avian myelocytomatosis viral oncogene homolog ... The protein encoded by this gene is a multifunctional nuclear phosphoprotein that plays a role in cell cycle progression apoptosis and cellular transformation. It ...
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